Natural remedies do absolutely nothing for my own anxiety issues (I had to go to the pharmacist), so I didn't think this would do much, but took a shot with my cat. She would start crying over absolutely nothing - 4 or 5 yowling panic attacks a day. This stuff took her 80%+ of the way back to a normal cat. She still will start crying once or twice a day, but it's less severe and I can usually just call out her name from the next room when I'm home, and she calms down.It took about a week to see some results, full results after 2-3 weeks for us. I mix it into her absolute favorite treat (Hartz bisques (needs to be something completely smooth for her to eat it (so not stews or anything with chunks)). She loves that bisque so much, she would still lap up half a bag of it quickly, even with a whole dose of Calming Care mixed in. After about 6 weeks, she stopped liking it so much and wouldn't finish it; so now I'm giving half of the Calming Care to her with half a bag of bisque, twice a day; so far she's down with that.